CELEBREX DRUG INFORMATION

Celebrex Label Information
Celebrex (celecoxib) is chemically designated as 4-[5-(4 methylphenyl)-3-(trifluoromethyl) 1H-pyrazol-1-yl] benzenesulfonamide and is a diaryl substituted pyrazole. It has the following chemical structure:

The empirical formula for celecoxib is C17H14F3N3O2S, and the molecular weight is 381.38.

Celebrex oral capsules contain 100 mg and 200 mg of celecoxib.

The inactive ingredients in Celebrex capsules include: croscarmellose sodium, edible inks, gelatin, lactose monohydrate, magnesium stearate, povidone, sodium lauryl sulfate and titanium dioxide.

Side Effects:

• Headache
• Indigestion
• Upper respiratory tract
• infection
• Diarrhea
• Sinus inflammation
• Stomach pain
• Nausea

Also linked to:

• Gastrointestinal bleeding, or ulcers
• Heart attacks
• Kidney disorders

If you have asthma, hives, or allergic reactions after taking aspirin or other NSAIDs, you should not take Celebrex, as well as if you have had an allergic reaction to sulfa drugs. Stomach ulcers are recognized complications in people who are treated with NSAIDs, and similar problems have occurred in people treated with Celebrex as well, though not as common. The longer Celebrex is taken, the more stomach problems are likely to occur. The short-term treatment also has risks involved. Some problems can happen without any warning, but symptoms can be recognized, such as gnawing or burning stomach pain, black, or tarry stools, or vomiting. Celebrex should be discontinued immediately if any of these symptoms appear.

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MORE INFO

Celebrex television ads have also been made without naming Celebrex in order to avoid Federal laws requiring side-effects to be stated on advertisements. Clinical trials that led to the approval of the drug Celebrex, as well as Vioxx, suggested that the drugs were safer on the stomach. The manufacturers conducted larger and longer-term studies in order to drop a warning about serious uclers that all NSAIDs carry. CLASS, which was a six-month clinical trial, failed to show a lower rate of serious ulcers in Celebrex patients compared with those on ibuprofen, the FDA reviewers concluded.

NSAIDs work by blocking enzymes known and COX-1 (an enzyme thought to keep stomach lining intact) and COX-2 (an enzyme involved in pain and inflammation). All NSAIDs, including aspirin and ibuprofen, inhibit COX-2. Celebrex blocks only COX-2 in order to provide pain relief minus stomach trouble. Because of this, it was hoped Celebrex would be safer than other NSAIDs for long-term use.

Celebrex is used to relieve symptoms for osteoarthritis and rheumatoid arthritis in adults. It is also used to reduce the number of colorectal polyps in patients with Familial Adenomatous Polyposis (FAP). FAP is an inherited disorder that results in the rectum and colon covered with many polyps. Celebrex has not been shown to reduce colorectal, duodenal or other FAP-related cancers. Whether or not the effects of Celebrex will last after treatment stops, is not known.